Rapid Synthesis of VX-745: p38 MAP Kinase Inhibition in Werner Syndrome Cells

Mark C Bagley, Terence Davis, Matthew C Dix, Michal J Rokicki, David Kipling

Bioorg Med Chem Lett. 2007 Sep 15;17(18):5107-10.

PMID: 17659871

Abstract:

The p38 mitogen-activated protein kinase inhibitor VX-745 is prepared rapidly and efficiently in a four-step sequence using a combination of conductive heating and microwave-mediated steps. Its inhibitory activity was confirmed in hTERT immortalized HCA2 and WS dermal fibroblasts at 0.5-1.0 microM concentration by ELISA and immunoblot assay, and displays excellent kinase selectivity over the related stress-activated kinase JNK.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP209410468	VX-745		209410-46-8	Price