Tales of Detailed Poly(A) Tails

Angela L Nicholson, Amy E Pasquinelli

Trends Cell Biol. 2019 Mar;29(3):191-200.

PMID: 30503240

Abstract:

Poly(A) tails are non-templated additions of adenosines at the 3' ends of most eukaryotic mRNAs. In the nucleus, these RNAs are co-transcriptionally cleaved at a poly(A) site and then polyadenylated before being exported to the cytoplasm. In the cytoplasm, poly(A) tails play pivotal roles in the translation and stability of the mRNA. One challenge in studying poly(A) tails is that they are difficult to sequence and accurately measure. However, recent advances in sequencing technology, computational algorithms, and other assays have enabled a more detailed look at poly(A) tail length genome-wide throughout many developmental stages and organisms. With the help of these advances, our understanding of poly(A) tail length has evolved over the past 5 years with the recognition that highly expressed genes can have short poly(A) tails and the elucidation of the seemingly contradictory roles for poly(A)-binding protein (PABP) in facilitating both protection and deadenylation.

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AP25038362	Poly(ethylene-co-propylene-co-5-methylene-2-norbornene)		25038-36-2	Price
LS772168	Poly[9,9-didodecylfluroenyl-2,7-yleneethylnylene]			Price