7-Nitroindazole Potentiates C-Fos Expression Induced by Muscle Tendon Vibration in the Spinal Cord

Alexander I Pilyavskii, Vladimir A Maisky, Andrey V Maznychenko, Alexander I Kostyukov

Muscle Nerve. 2012 Apr;45(4):597-602.

PMID: 22431094

Abstract:

Introduction:




Expression of c-fos initiated by muscle proprioceptive signaling was studied in rats after inhibition of neuronal nitric oxide synthase (nNOS) with administration of 7-nitroindazole (7-NI).













Methods:




Fos-immunoreactive (Fos-ir) neurons were visualized immunohistochemically in the lumbar cord after vibration of the Achilles tendon and/or 7-NI systemic injections.













Results:




The total number of Fos-ir interneurons and motoneurons (per slice) was significantly greater in the 7-NI-pretreated and tendon-vibrated (7-NI + Tv) group than in the isolated tendon vibration group (Tv group). The greatest increases in the number of Fos-ir neurons were found in the L4 (+100%) and L5 (+105%) segments (P < 0.05).













Conclusions:




Suppression of NO release after introduction of 7-NI was associated with potentiation of Fos immunoreactivity induced by muscle proprioceptive signaling within distinctive regions of the spinal cord.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2942429	7-Nitroindazole		2942-42-9	Price