(-)-α-Bisabolol-induced Gastroprotection Is Associated With Reduction in Lipid Peroxidation, Superoxide Dismutase Activity and Neutrophil Migration

Nayrton Flávio Moura Rocha, Gersilene Valente de Oliveira, Fernanda Yvelize Ramos de Araújo, Emiliano Ricardo Vasconcelos Rios, Alyne Mara Rodrigues Carvalho, Leonardo Freire Vasconcelos, Danielle Silveira Macêdo, etc.

Eur J Pharm Sci. 2011 Nov 20;44(4):455-61.

PMID: 21924353

Abstract:

This work examined the gastroprotection of (-)-α-bisabolol, an unsaturated optically active sesquiterpene alcohol obtained by the direct distillation essential oil from plants. (-)-α-Bisabolol has been described as a compound capable of reducing the gastric ulcer area in response to absolute ethanol. We evaluated the gastroprotection of (-)-α-bisabolol in ethanol-induced gastric lesions model through histopathological assessment, measurement of the membrane lipids peroxidation (MDA), myeloperoxidase (MPO) activity, superoxide dismutase (SOD) activity, catalase (CAT) activity and the nitrite amount. Our results showed that (-)-α-bisabolol was able to reduce injuries associated with the administration of ethanol and the formation of thiobarbituric acid reactive substances (MDA) was also able to increase SOD activity and reduce the influx of cells inflammatory (neutrophils) in the gastric mucosa. The effect of (-)-α-bisabolol seems to be unrelated to the nitric oxide. (-)-α-Bisabolol caused a reduction of catalase activity. These findings show that (-)-α-bisabolol is able to decrease oxidative stress and inflammatory event associated with the lesions induced by ethanol.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23089261	(−)-α-Bisabolol		23089-26-1	Price