Amino acid metabolite standards are internal standard substances for quantitative analysis of amino acid metabolites. The quantitative analysis methods of amino acid metabolites in biological samples mainly include ion exchange chromatography analysis-post column ninhydrin derivative method, precolumn fluorescent derivative-reversed phase high performance liquid chromatography, high performance liquid chromatography-electrospray tandem mass spectrometer and others.
Amino acid metabolite standards are essential for quantitative analysis of amino acid metabolites by using the above analysis methods, and there are many types of amino acid metabolite standards, which can be selected according to the analysis requirements. Amino acid metabolite standards mainly include aspartic acid (Asp), glycine (Gly), lysine (Lys), serine (Ser), alanine (Ala), tyrosine (Tyr), methionine (Met), glutamic acid (Glu), phenylalanine (Phe), aspartic amide (Asn), glutamine (Gln) and others.
Plasma metabolomics analysis of gastric cancer: Gastric cancer is one of the most common malignant tumors. However, due to the lack of specific clinical symptoms of gastric cancer, many patients have reached the middle and advanced stage at the time of diagnosis, which leads to the five-year survival rate of gastric cancer is low. In recent years, studies have revealed the close relationship between amino acid metabolites and gastric cancer. Using amino acid metabolite standards, changes in the levels of amino acid metabolites in human plasma can be analyzed, which is of vital importance for diagnosis and treatment of this disease. The amino acid metabolite standards used in this analysis method include L-lysine (Lys), L-tryptophan (Trp), L-phenylalanine (Phe), L-methionine (Met), L-threonine (Thr), L-tyrosine (Tyr), L-serine (Ser), L-alanine (Ala) and others.
Plasma metabolomics analysis in hypertensive diseases: Hypertension, also called essential hypertension, is a clinical common and frequently-occurring disease, which can induce cardiovascular event and cause disability and death. Using amino acid metabolite standards to analyze amino acid metabolites can look for symptoms of biological information, which is necessary for the prevention and treatment of hypertension.
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