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Pharmacology standards are the reference materials that play an important role in the field of life science. A pharmacology standard is a substance or material that has been determined to have one or more sufficiently uniform characteristic values, which can be used to calibrate measuring instruments and devices, evaluate measurement and analysis methods, measure the characteristic values of a substance or material, and assess the operating skill of the analyst. Pharmacology standards have three distinct characteristics. First, the characteristic values of pharmacology standards have the characteristics of accuracy, uniformity and stability. Secondly, the amount of pharmacology standards is transitive. Third, pharmacology standards are measurement standards in physical form. Commonly used pharmacology standards include fenofibric acid, bufexamac, chlorpromazine hydrochloride, azaperol and others.
Analyze the impurities in the pharmaceuticals: Impurities in the pharmaceuticals may cause adverse side reactions and affect the efficacy of pharmaceuticals. Using pharmacology standards to analyze the type and content of pharmaceutical impurities can guide to optimize the synthetic route, experimental conditions and other factors, which can be used to avoid producing pharmaceutical impurities or reduce them to a minimum.
Separation of chiral drugs: Another use of pharmacology standard is in the field of chiral drugs separation. Based on the standard curves made by the pharmacology standards, the chromatographic method can realize the efficient separation of chiral drugs. For example, chiral drugs of 2-arylpropionic acids can be separated by high performance liquid chromatography (HPLC) based on pharmacology standards.
Others: In addition to the above mentioned, pharmacology standards can be used in many other fields. For example, using pharmacology standards, residual solvents in pharmaceuticals can be accurately detected to ensure the safety of pharmaceuticals. Moreover, measuring the content of certain substances in biological samples could help doctors better diagnose diseases by virtue of pharmacology standards. Furthermore, it could also help scientists study the mechanism of diseases, which is of great importance for life sciences researches.
Alfa Chemistry is one of the largest providers of pharmacology standards in the world and the quality assurance is of prime importance to Alfa Chemistry. The solvent from Alfa Chemistry in the world is synonymous with reliability and excellent quality. Because of the exacting nature of our business and the regulatory demands placed upon our industry, Alfa Chemistry continues to be at the forefront in terms of compliance, accreditations and certifications.