Drugs refer to chemical substances that can affect the physiological functions of the body's organs and cell metabolism, and have the effects of preventing, treating and diagnosing diseases. Drug metabolism refers to the process in which a series of chemical reactions may occur when drugs are absorbed and distributed under the action of various enzymes in the body and the environment of body fluids, leading to changes in the chemical structure of drugs.
Drug metabolism is a process that a drug must go through when it takes effect. For different drugs, their metabolites are bound to be different. After long-term drug research and accumulation, drugs & metabolites standards have been accumulated accordingly. Using standard products for comparison can greatly improve the efficiency of research and development. Use drug and metabolite standards that meet chromatographic standards as analytical reference materials to study drug metabolism.
Application fields
Drug development: In the process of drug research and development, drug metabolite research is an important part and an important source of new drug discovery. In general, the process of biotransformation is the inactivation process of pharmacologically active compounds. However, it is now found that the metabolites of many drugs have higher pharmacological activity or more ideal pharmacokinetic properties than the original drugs, and have been developed into drugs with high efficiency and low side effects. In order to simplify the research process, it is a common research method to use standard materials for investigation and analysis. Chromatographic analysis is a commonly used analytical method in the process of drug metabolism research. Drugs and metabolite standards can be used for qualitative and quantitative analysis to determine the types of drugs and metabolites.
Poison test: Drug toxicology research is the process of studying the toxicity of drugs to organisms, including their severity, frequency and mechanism of toxicity. The most important part of drug toxicity research is to test its metabolites. The determination of the type of metabolites needs to be compared with possible standard substances, so as to reverse the types of substances that cause poisoning, determine the poisons, and deduce the toxicological process.
Why choose Alfa Chemistry?
Alfa Chemistry is one of the largest providers of drugs & metabolites standards in the world and the quality assurance is of prime importance to Alfa Chemistry. The solvent from Alfa Chemistry in the world is synonymous with reliability and excellent quality. Because of the exacting nature of our business and the regulatory demands placed upon our industry, Alfa Chemistry continues to be at the forefront in terms of compliance, accreditations and certifications.
References
Zhoupeng, Z.; et al. Drug metabolism in drug discovery and development [J]. Acta Pharmaceutica Sinica B 8(5) 721–732.
Ramaekers，G. J.; et al. Drugs and Driving Research in Medicinal Drug Development. Trends in Pharmacological Sciences, 38(2014) 319-321.
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