NiO/SWCNTs Coupled With an Ionic Liquid Composite for Amplified Carbon Paste Electrode; A Feasible Approach for Improving Sensing Ability of Adrenalone and Folic Acid in Dosage Form

Safoora Afshar, Hassan Ali Zamani, Hassan Karimi-Maleh

J Pharm Biomed Anal. 2020 May 28;188:113393.

PMID: 32504973

Abstract:

Electrochemical sensors have shown great appeal for the simultaneous analysis of pharmaceutical compounds. In this way, the presence study described first electroanalytical sensor for simultaneous determination of adrenalone and folic acid. The two-amplified voltammetric sensor was developed by modifying carbon paste electrode (CPE) with NiO/SWCNTs composite and 1-butyl-3-methylimidazolium methanesulfonate (1B3MIMS) and used for simultaneous determination of adrenalone and folic acid. The NiO/SWCNTs was synthesised by a fast and low-cost precipitation strategy and then characterised by EDS, FESEM and XRD methods. The results confirmed a particle size range of ⁓ 26.93-33.87 nm for NiO nanoparticle decorated at SWCNTs. The cyclic voltammetric investigation showed that oxidation potentials of adrenalone and folic acid depend on changing the pH value. The maximum oxidation current for the simultaneous analysis of two compounds occurred at pH = 7.0. In this condition, the sensor showed linear dynamic range 0.01-400 μM and 0.3-350 μM for determination of adrenalone and folic acid, respectively. The NiO/SWCNTs/1B3MIMS/CPE was then used as an ultrasensitive electroanalytical sensor for determination of adrenalone and folic acid in injection samples with recovery ratio between 98.2-103.66 %.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP342789815	1-Butyl-3-methylimidazolium methanesulfonate		342789-81-5	Price