Rutin Hydrate Ameliorates Cadmium Chloride-Induced Spatial Memory Loss and Neural Apoptosis in Rats by Enhancing Levels of Acetylcholine, Inhibiting JNK and ERK1/2 Activation and Activating mTOR Signalling

Ghada A Abdel-Aleem, Eman F Khaleel

Arch Physiol Biochem. 2018 Oct;124(4):367-377.

PMID: 29214892

Abstract:

This study aimed at studying the potential neuroprotective effect of Rutin hydrate (RH) alone or in conjugation with α-tocopherol against cadmium chloride (CdCl2)-induced neurotoxicity and cognitive impairment in rats and to investigate the mechanisms of action. Rats intoxicated with CdCl2 were treated with the vehicle, RH, α-tocopherol or combined treatment were examined, and compared to control rats received vehicle or individual doses of either drug. Data confirmed that RH improves spatial memory function by increasing acetylcholine availability, boosting endogenous antioxidant potential, activating cell survival and inhibiting apoptotic pathways, an effect that is more effective when RH was conjugated with α-tocopherol. Mechanism of RH action includes activation of PP2A mediated inhibiting of ERK1/2 and JNK apoptotic pathways and inhibition of PTEN mediated activation of mTOR survival pathway. In conclusion, RH affords a potent neuroprotection against CdCl2-induced brain damage and memory dysfunction and co-administration of α-tocopherol enhances its activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP207671509	Rutin hydrate		207671-50-9	Price