Anti-scratching Behavioral Effects of N-stearoyl-phytosphingosine and 4-hydroxysphinganine in Mice

Kwon-Ryeol Ryu, Bomi Lee, In-Ah Lee, Sekwan Oh, Dong-Hyun Kim

Lipids. 2010 Jul;45(7):613-8.

PMID: 20585891

Abstract:

N-Stearoyl-phytosphingosine (SPS) and 4-hydroxysphinganine (phytosphingosine, PS), which are sphingolipids frequently found in mammalian skin, plants, and yeast, have been used as ingredients in cosmetics. In mice, treatment with SPS and PS inhibited histamine-induced scratching behavior and vascular permeability. These agents inhibited the expression of the allergic cytokines, IL-4 and TNF-alpha, and the activation of the transcription factors, NF-kappaB and c-jun, in histamine-stimulated skin tissues. These agents also showed potent anti-histamine effects in the Magnus test using guinea pig ileum. Based on these results, SPS and PS may improve scratching behavioral reactions in skin by regulating the action of histamine and the activation of the transcription factors NF-kappaB and c-jun.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34354886	N-Stearoyl-phytosphingosine		34354-88-6	Price