Combined Use of Ionic Liquid and β-CD for Enantioseparation of 12 Pharmaceuticals Using CE

Lihua Zuo, Heng Meng, Jingjing Wu, Zhen Jiang, Shuying Xu, Xingjie Guo

J Sep Sci. 2013 Feb;36(3):517-23.

PMID: 23303483

Abstract:

In this study, the enantioseparation of zopiclone, repaglinide, chlorphenamine maleate, brompheniramine maleate, dioxopromethazine hydrochloride, promethazine hydrochloride, liarozole, carvedilol, homatropine hydrobromide, homatropine methylbromide, venlafaxine, and sibutramine hydrochloride has been investigated using β-CD in combination with a chiral ionic liquid (IL), 1-ethyl-3-methylimidazolium-L-lactate. The influence of the type of IL and its concentration, BGE pH, and chain length of the IL cations on the resolution are discussed. Finally, the proposed method was successfully applied for the chiral impurity determination of eszopiclone in pharmaceutical tablets after validation with respect to accuracy and precision, linearity range, selectivity, repeatability, LOD and LOQ. It is assessed that the chiral impurity determination in the commercial tables is fewer than 0.1%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP878132195	1-Ethyl-3-methylimidazolium L-(+)-lactate		878132-19-5	Price