[Acupuncture Intervention Improves Behavior Reactions and Learning-memory Ability in Post-traumatic Stress Disorder Rats]

Yi-Kun Zhao, Ya-di Han, Yan-Feng Zhang, Tian-Tian Zhu, Chong-Bing Ma, Zhong-Ting Zhao, Xing-Ke Yan

Zhen Ci Yan Jiu. 2018 Sep 25;43(9):562-6.

PMID: 30232864

Abstract:

Objective:




To observe the therapeutic effect of acupuncture in the treatment of post-traumatic stress disorder (PTSD)-induced abnormal behavior reactions and learning-memory ability in rats with traumatic injury.













Methods:




Sixty male SD rats were randomly divided into control, model, model+animal capturing (capturing), medication and acupuncture groups (n=12 rats in each). The PTSD model was established by "electric shock plus incarceration" method. Acupuncture was applied to "Baihui" (GV 20), and unilateral "Neiguan" (PC 6), "Shenmen" (HT 7) and "Taichong" (LR 3) once daily for 12 days. The rats in the medication group were treated by gavage of Paroxetine Hydrochloride solution (0.42 mg/mL), once daily for 12 days. The open field test containing horizontal (crossing grid lines) and rearing tests was performed for examining the rats' locomotor activity and anxiety-like behavior; and location navigation (escape latency) and special probe tests (platform quadrant crossing times) of Morris water maze tasks were detected for assessing the rats' learning-memory ability. On day 12 of the experiments, the rats were submitted to 3 consecutive sessions of open field tests for observing the time of familiar objects (TF) and the time of novelty object (TN) of exploration in 5 min (an object-location and an object-recognition tasks), followed by calculating the discrimination index [DI=(TN-TF)/(TN+TF)x100%].













Results:




After modeling, compared with the control group, the numbers of crossed grids and rearing, and DI were significantly decreased (P<0.05), while the number of fecal pellets and escape latency were significantly increased in both the model and capturing groups (P<0.05). After the intervention, the number of both crossed grids and rearing, platform quadrant crossing times, and DI were considerably increased (P<0.05), and the rats' escape latency and fecal pellet number were obviously decreased in both medication and acupuncture groups relevant to the model and capturing groups (P<0.05). No significant differences were found between the acupuncture and medication groups in the above mentioned 5 indexes (P>0.05)..













Conclusion:




Acupuncture can effectively reduce anxiety-like behavior and improve the impaired learning-memory ability in PTSD rats.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1062606125	Venlafaxine-D6 hydrochloride solution		1062606-12-5	Price
AP1181578711	Trazodone-D6 hydrochloride solution		1181578-71-1	Price
AP1184983423	Cyclobenzaprine-D3 hydrochloride solution		1184983-42-3	Price
AP1217648753	Nortilidine-D3 hydrochloride solution		1217648-75-3	Price
AP1219804020	Methylphenidate-d9 hydrochloride solution		1219804-02-0	Price
AP1231710636	Butylone-d3 hydrochloride solution		1231710-63-6	Price
AS212210	Tilidine-D6 hydrochloride solution			Price
AS212261	Duloxetine-D3 hydrochloride solution			Price
AS212278	(±)-Sertraline-D3 hydrochloride solution			Price
AS212355	Anabasine-d4 hydrochloride solution			Price
AS212639	Atomoxetine-d7 hydrochloride solution			Price
AS27230	Eutylone-D5 hydrochloride solution			Price
AS27248	α-Pyrrolidinovalerophenone-D8 hydrochloride solution			Price
AS27249	Pentylone-D3 hydrochloride solution			Price
AP1346599163	MDPBP-D8 hydrochloride solution		1346599-16-3	Price
AP1346746846	2C-B-FLY-D4 hydrochloride solution		1346746-84-6	Price
AP1435933860	Promethazine-D3 hydrochloride solution		1435933-86-0	Price