Isolation and Characterization of Novel Geldanamycin Analogues

Zhihao Hu, Yaoquan Liu, Zong-Qiang Tian, Wei Ma, Courtney M Starks, Rika Regentin, Peter Licari, David C Myles, C Richard Hutchinson

J Antibiot (Tokyo). 2004 Jul;57(7):421-8.

PMID: 15376554

Abstract:

New geldanamycin analogues with novel structures arising from direct microbial bioconversion and a genetically engineered geldanamycin producer were isolated and characterized. Three compounds, 15-hydroxygeldanamycin, a tricyclic geldanamycin analog (KOSN-1633), and methyl-geldanamycinate), were isolated after geldanamycin was added to a growing culture of the herbimycin producing strain-Streptomyces hygroscopicus AM-3672. Two related compounds, 17-formyl-17-demethoxy-18-O,-21-O-dihydrogeldanamycin and 17-hydroxymethyl-17-demethoxygeldanamycin were isolated from S. hygroscopicus NRRL 3602/pKOS279-78, a geldanamycin-producing strain containing various genes isolated from S. hygroscopicus AM-3672. Compared with geldanamycin, these five new compounds exhibited reduced cytotoxicity against SKBr3 cancer cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP70563585-A	Herbimycin A from Streptomyces hygroscopicus		70563-58-5	Price