[Animal Experimental and Human Pharmacologic Studies With phase-II Metabolites of Triamterene]

K D Völger

Arzneimittelforschung. 1991 May;41(5):499-506.

PMID: 1898420

Abstract:

Animal Experiments and Human Studies with the Phase-II Metabolite of Triamterene The described animal experiments as well as the pharmacological investigations in man show the diuretic efficacy of the phase-II metabolite of triamterene (CAS 396-01-0), OH-TA-ester. As demonstrated in the present investigation, a phase-II metabolite can not be considered only as an ineffective conjugation product, formed to accomplish the excretion of a foreign compound, but also it must be considered as an important factor in the therapy, if its pharmacologic efficacy has been established, moreover if as a result of disease-related alterations in the pharmacokinetics the phase-II metabolite cumulates.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1006231	Triamterene Related Compound A		1006-23-1	Price