Metal-free Photocatalytic thiol-ene/thiol-yne Reactions

Sarbjeet Kaur, Gaoyuan Zhao, Evan Busch, Ting Wang

Org Biomol Chem. 2019 Feb 13;17(7):1955-1961.

PMID: 30334562

Abstract:

The organic photocatalyst (9-mesityl-10-methylacridinum tetrafluoroborate) in the presence of visible light is used to initiate thiol-ene and thiol-yne reactions. Thiyl radicals are generated upon quenching the photoexcited catalyst with a range of thiols. The highlighted mild nature of the reaction conditions allows a broad substrate scope of the reactants. Relying on this efficient metal-free condition, both thiol-ene and thiol-yne reactions between carbohydrates and peptides could be realized in excellent yields.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33462816	Cyclopropyldiphenylsulfonium tetrafluoroborate		33462-81-6	Price