Home
Resources
Publications
Aggregation of Antihistamines in Aqueous Solution. The Effect of Electrolyte on the Miscellar Properties of Some Diphenylmethane Derivatives

Aggregation of Antihistamines in Aqueous Solution. The Effect of Electrolyte on the Miscellar Properties of Some Diphenylmethane Derivatives

D Attwood, O K Udeala

J Pharm Pharmacol. 1975 Jun;27(6):395-9.

PMID: 237086

Abstract:

The effect of sodium chloride on the micellar properties of the antihistamines, dephenhydramine hydrochloride, bromodiphenhydramine hydrochloride, chlorcyclizine hydrochloride and diphenylpyraline hydrochloride in aqueous solution has been investigated by light scattering and viscometric methods. The drugs behaved as typical ionic surfactants showing an increase in aggregation number and decrease in critical micelle concentration as the electrolyte concentration was increased over the range 0.05 to 0.154 mol kg-minus1. A linear relation between log critical micelle concentration and log counterion concentration was established, from which values of the degree of ionization and the free energy of micellization were calculated. The intrinsic viscosity was decreased by the addition of electrolyte and this has been attributed to a decrease in micellar hydration due to a removal of hydrogen-bonded water.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1808124-A	Bromodiphenhydramine Hydrochloride		1808-12-4	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: