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[Behavior of High- And Low-Anxiety Rats After Modulation of GABAergic Transmission in Basolateral Amygdala]

[Behavior of High- And Low-Anxiety Rats After Modulation of GABAergic Transmission in Basolateral Amygdala]

M P Rysakova, I V Pavlova

Ross Fiziol Zh Im I M Sechenova. 2014 Jun;100(6):736-49.

PMID: 25665398

Abstract:

The influence of GABA(A) receptor agonist (muscimol hydrobromide, 0.1 μg/0.5 μL) and antagonist (bicuculline methiodide, 0.2 μg/0.5 μL) injections into the right and the left basolateral amygdala on the behavior of the high- and low-anxiety rats was investigated in elevated plus-maze test. High- and low-anxiety rats had different sensitivities to injections of GABA receptor agents. Administration of muscimol increased open-arm time only in the high-anxiety rats, indicating anxiolytic-like effect. Injection of bicuculline increased aggression of all rats, as well as enhanced locomotion and exploration in high-anxiety rats, increased open-arm time and emotionality in the low-anxiety animals. More powerful changes in behavior of rats were revealed after injections of muscimol into the left amygdala of high-anxiety rats and bicuculline into the right amygdala of low-anxiety ones. The results evidence the existence of individual typological and interhemispheric differences in functioning of the amygdalar GABAergic system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18174726	Muscimol hydrobromide		18174-72-6	Price

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