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Biodistribution of PLGA and PLGA/chitosan Nanoparticles After Repeat-Dose Oral Delivery in F344 Rats for 7 Days

Biodistribution of PLGA and PLGA/chitosan Nanoparticles After Repeat-Dose Oral Delivery in F344 Rats for 7 Days

Sara M Navarro, Caleb Darensbourg, Linda Cross, Rhett Stout, Diana Coulon, Carlos E Astete, Timothy Morgan, Cristina M Sabliov

Ther Deliv. 2014 Nov;5(11):1191-201.

PMID: 25491670

Abstract:

Aim:
To quantify in vivo the biodistribution of poly(lactic-co-glycolic) acid (PLGA) and PLGA/chitosan nanoparticles (PLGA/Chi NPs) and assess if the positive charge of chitosan significantly enhances nanoparticle absorption in the GI tract.
Material & methods:
PLGA and PLGA/Chi NPs covalently linked to tetramethylrhodamine-5-isothiocyanate (TRITC) were orally administered to F344 rats for 7 days, and the biodistribution of fluorescent NPs was analyzed in different organs.
Results:
The highest amount of particles (% total dose/g) was detected for both treatments in the spleen, followed by intestine and kidney, and then by liver, lung, heart and brain, with no significant difference between PLGA and PLGA/Chi NPs.
Conclusion:
Only a small percentage of orally delivered NPs was detected in the analyzed organs. The positive charge conferred by chitosan was not sufficient to improve the absorption of the PLGA/Chi NPs over that of PLGA NPs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80724192	Tetramethylrhodamine-5-isothiocyanate		80724-19-2	Price

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