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Effect of Progranulin on Migration and Invasion of Human Colon Cancer Cells

Effect of Progranulin on Migration and Invasion of Human Colon Cancer Cells

Jia Zhao, Xingtai Li, Jiamei Liu, Wenhua Jiang, Dezhong Wen, Hui Xue

J Coll Physicians Surg Pak. 2018 Aug;28(8):607-611.

PMID: 30060789

Abstract:

Objective:
To investigate the effects of progranulin on migration and invasion of human colon cancer cells.
Study design:
An experimental study.
Place and duration of study:
Department of Histology and Embryology, College of Basic Medical Sciences, Jilin University, Changchun, China, from October 2015 to July 2017.
Methodology:
Cell transfection was used to obtain progranulin knocked down/overexpressing cells. MTT and soft agar assay were applied to investigate the cell growth. Migration and invasion were detected using transwell assay.
Results:
Tumor growth, migration and invasion decreased in progranulin knocked down cells and increased in progranulin overexpressing cells. The decrease was recovered when exogenous progranulin was added. Progranulin-induced migration and invasion were inhibited by neamine.
Conclusion:
Progranulin has a direct effect on tumor growth, migration, and invasion of human colon cancer cells. It may serve as a potential therapeutic target for human colon cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413496	Progranulin human			Price

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