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Evaluation of the Analgesic Properties of Acepromazine Maleate, Oxymorphone, Medetomidine and a Combination of Acepromazine-Oxymorphone

Evaluation of the Analgesic Properties of Acepromazine Maleate, Oxymorphone, Medetomidine and a Combination of Acepromazine-Oxymorphone

Matthew D Barnhart, John A E Hubbell, William W Muir

Vet Anaesth Analg. 2000 Jul;27(2):89-96.

PMID: 28404059

Abstract:

Objective:
To determine the presence and duration of analgesia after oxymorphone, acepromazine maleate, acepromazine-oxymorphone combination and medetomidine administration in dogs.
Study design:
Blinded, controlled study.
Animals:
Six adult beagle dogs.
Methods:
Each dog participated in five trials receiving acepromazine maleate (0.2 mg kg-1 IM), oxymorphone (0.2 mg kg-1 IM), acepromazine-oxymorphone drug combination (0.2 mg kg-1 each IM), medetomidine (20 μg kg-1 IM) and sterile saline (control). Two specially designed instruments were used for analgesia determination: a heat device (HD) utilized a linear ramped intensity incandescent bulb and a pressure device (PD) consisted of a pneumatic cylinder that protruded a 2.5-cm bolt. The minimum pressure and heat necessary to produce an avoidance response were determined. Analgesia testing was performed prior to and at 30-minute intervals for six hours after drug administration.
Results:
Oxymorphone, acepromazine-oxymorphone and medetomidine significantly elevated both pressure and heat response thresholds compared to controls and acepromazine. Both medetomidine and acepromazine-oxymorphone provided a significantly longer duration of analgesia than oxymorphone. No adverse effects were observed at any of the thermal or pressure application sites.
Conclusions:
Oxymorphone, medetomidine and acepromazine-oxymorphone produced significant analgesia with medetomidine and acepromazine-oxymorphone providing the longest duration of analgesia.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3598376-A	Acepromazine maleate		3598-37-6	Price

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