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Facile Fabrication of Polyurethane Microcapsules Carriers for Tracing Cellular Internalization and Intracellular pH-triggered Drug Release

Facile Fabrication of Polyurethane Microcapsules Carriers for Tracing Cellular Internalization and Intracellular pH-triggered Drug Release

Yuqing Niu, Florian J Stadler, Jun Song, Siping Chen, Shiguo Chen

Colloids Surf B Biointerfaces. 2017 May 1;153:160-167.

PMID: 28236792

Abstract:

A tailor-made traceable pH-sensitive drug delivery system based on polyurethane (PU) microcapsules was fabricated using a facile double-emulsion method containing 3,3'-dioctadecyloxacarbocyanine perchlorate, doxorubicin (DOX) and sodium bicarbonate (NaHCO3). When PU microcapsules were immersed in acidic media, NaHCO3 could react with the H+ to quickly produce CO2 bubbles to puncture the PU shell, resulting in rapid release of DOX to promptly reach the intracellular drug therapeutic threshold to kill cancer cells in a short period. Confocal laser scanning microscopic analysis showed that these traceable pH-sensitive drug carriers can be easily internalized by BGC 823 and Hela cells, and the loaded DOX can quickly release from PU microcapsules in the endo-/lysosomes to be mainly resided in cell nuclei. This traceable pH-sensitive drug carrier can achieve on-demand controlled release profiles for visualization of cancer therapy. Thus, it is a potential candidate for anticancer drug delivery system in advanced cancer therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34215571	3,3′-Dioctadecyloxacarbocyanine perchlorate		34215-57-1	Price

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