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Formulation Development and Characterization of Meclizine Hydrochloride Sublimated Fast Dissolving Tablets

Formulation Development and Characterization of Meclizine Hydrochloride Sublimated Fast Dissolving Tablets

Sateesh Kumar Vemula, Mohan Vangala

Int Sch Res Notices. 2014 Aug 25;2014:281376.

PMID: 27355021

Abstract:

The intention of present research is to formulate and develop the meclizine hydrochloride fast dissolving tablets using sublimation method to enhance the dissolution rate. In this study an attempt was made to fasten the drug release from the oral tablets by incorporating the superdisintegrants and camphor as sublimating agent. The prepared fast dissolving tablets were subjected to precompression properties and characterized for hardness, weight variation, friability, wetting time, water absorption ratio, and disintegration time. From in vitro release studies, the formulation F9 exhibited fast release profile of about 98.61% in 30 min, and disintegration time 47 sec when compared with other formulations. The percent drug release in 30 min (Q 30) and initial dissolution rate for formulation F9 was 98.61 ± 0.25%, 3.29%/min. These were very much higher compared to marketed tablets (65.43 ± 0.57%, 2.18%/min). The dissolution efficiency was found to be 63.37 and it is increased by 1.4-fold with F9 FDT tablets compared to marketed tablets. Differential scanning calorimetry and Fourier transform infrared spectroscopy studies revealed that there was no possibility of interactions. Thus the development of meclizine hydrochloride fast dissolving tablets by sublimation method is a suitable approach to improve the dissolution rate.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP31884772	Meclizine hydrochloride		31884-77-2	Price

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