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Green Approach Towards the Determination of Hydroxyzine Dihydrochloride in Pure and Pharmaceutical Dosage Forms

Green Approach Towards the Determination of Hydroxyzine Dihydrochloride in Pure and Pharmaceutical Dosage Forms

Amina Mumtaz, Shahid Hussain, Muhammad Yasir

Pak J Pharm Sci. 2014 Sep;27(5):1157-62.

PMID: 25176372

Abstract:

A simple eco-friendly method has been developed for detection of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms. Both conventional system and microwave assisted procedures are used for the development of color. The blue coloured complex is measured spectrophotometrically at 750nm. Peak shift in FT-IR spectra also indicated the formation of complex. The reaction obeys Beer's law over the concentration range of 50- 250βg/mL of hydroxyzine dihydrochloride. The precision value (intra-day and inter-day RSD) for the drug is not greater than 0.79% and recoveries were found to be in range of 99.01-99.99%. The designed method is applicable for periodic determination of hydroxyzine dihydrochloride in pure and pharmaceutical dosage forms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2192203-B	Hydroxyzine Dihydrochloride		2192-20-3	Price

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