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Human Polynucleotide Phosphorylase (hPNPase(old-35)): An Evolutionary Conserved Gene With an Expanding Repertoire of RNA Degradation Functions

Human Polynucleotide Phosphorylase (hPNPase(old-35)): An Evolutionary Conserved Gene With an Expanding Repertoire of RNA Degradation Functions

S K Das, S K Bhutia, U K Sokhi, R Dash, B Azab, D Sarkar, P B Fisher

Oncogene. 2011 Apr 14;30(15):1733-43.

PMID: 21151174

Abstract:

Human polynucleotide phosphorylase (hPNPase(old-35)) is an evolutionary conserved RNA-processing enzyme with expanding roles in regulating cellular physiology. hPNPase(old-35) was cloned using an innovative 'overlapping pathway screening' strategy designed to identify genes coordinately regulated during the processes of cellular differentiation and senescence. Although hPNPase(old-35) structurally and biochemically resembles PNPase of other species, overexpression and inhibition studies reveal that hPNPase(old-35) has evolved to serve more specialized and diversified functions in humans. Targeting specific mRNA or non-coding small microRNA, hPNPase(old-35) modulates gene expression that in turn has a pivotal role in regulating normal physiological and pathological processes. In these contexts, targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415155	Polynucleotide phosphorylase human			Price

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