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Human Polynucleotide Phosphorylase (hPNPaseold-35): Should I Eat You or Not--That Is the Question?

Human Polynucleotide Phosphorylase (hPNPaseold-35): Should I Eat You or Not--That Is the Question?

Upneet K Sokhi, Swadesh K Das, Santanu Dasgupta, Luni Emdad, Rita Shiang, Robert DeSalle, Devanand Sarkar, Paul B Fisher

Adv Cancer Res. 2013;119:161-90.

PMID: 23870512

Abstract:

RNA degradation plays a fundamental role in maintaining cellular homeostasis whether it occurs as a surveillance mechanism eliminating aberrant mRNAs or during RNA processing to generate mature transcripts. 3'-5' exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago in the context of terminal differentiation and senescence through a novel "overlapping pathway screening" approach. Since then, significant insights have been garnered about this exoribonuclease and its repertoire of expanding functions. The objective of this review is to provide an up-to-date perspective of the recent discoveries made relating to hPNPaseold-35 and the impact they continue to have on our comprehension of its expanding and diverse array of functions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42415155	Polynucleotide phosphorylase human			Price

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