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IL-36 Promotes Anti-Viral Immunity by Boosting Sensitivity to IFN-α/β in IRF1 Dependent and Independent Manners

IL-36 Promotes Anti-Viral Immunity by Boosting Sensitivity to IFN-α/β in IRF1 Dependent and Independent Manners

Peng Wang, Ana M Gamero, Liselotte E Jensen

Nat Commun. 2019 Oct 16;10(1):4700.

PMID: 31619669

Abstract:

The functions of the IL-36 cytokines remain poorly understood. We report a previously unrecognized mechanism whereby IL-36 promotes innate antiviral immunity in mouse and human models of herpes simplex virus-1 (HSV-1) infections. HSV-1 actively suppresses production of type I interferon (IFN); our data reveal that IL-36 overcomes this immune evasion strategy by increasing cellular sensitivity to IFN. IL-36β deficient mice display impaired IFN responses and poorly restrict viral replication in skin keratinocytes. In mouse and human keratinocytes IL-36 elicits an antiviral state driven by STAT1 and STAT2 via enhanced expression of IFNAR1 and IFNAR2 subunits of the type I IFN receptor. The degree of IFN regulatory factor 1 (IRF1) involvement is species dependent, with IRF1 playing a more prominent role in human cells. Similar mechanisms are activated by IL-1. Overall, IL-36 acts as an antiviral cytokine by potentiating type I IFN signaling and thereby upholds immune responses to viruses that limit the production of IFNs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413397	IL-36β mouse			Price

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