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Molecularly Imprinted Polymer Based Potentiometric Sensor for the Determination of Hydroxyzine in Tablets and Biological Fluids

Molecularly Imprinted Polymer Based Potentiometric Sensor for the Determination of Hydroxyzine in Tablets and Biological Fluids

Mehran Javanbakht, Solmaz Eynollahi Fard, Ali Mohammadi, Majid Abdouss, Mohammad Reza Ganjali, Parviz Norouzi, Leila Safaraliee

Anal Chim Acta. 2008 Mar 31;612(1):65-74.

PMID: 18331859

Abstract:

Molecular imprinting is a useful technique for the preparation of functional materials with molecular recognition properties. In this work, a biomimetic potentiometric sensor, based on a non-covalent imprinted polymer, was fabricated for the recognition and determination of hydroxyzine in tablets and biological fluids. The molecularly imprinted polymer (MIP) was synthesized by precipitation polymerization, using hydroxyzine dihydrochloride as a template molecule, methacrylic acid (MAA) as a functional monomer and ethylene glycol dimethacrylat (EGDMA) as a cross-linking agent. The sensor showed a high selectivity and a sensitive response to the template in aqueous system. The MIP-modified electrode exhibited a Nernstian response (29.4+/-1.0 mV decade(-1)) in a wide concentration range of 1.0x10(-6) to 1.0x10(-1) M with a lower detection limit of 7.0x10(-7) M. The electrode demonstrated a response time of approximately 15s, a high performance and a satisfactory long-term stability (more than 5 months). The method has the requisite accuracy, sensitivity and precision to assay hydroxyzine in tablets and biological fluids.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP2192203-B	Hydroxyzine Dihydrochloride		2192-20-3	Price

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