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N-acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) Benzenesulfonamide Class of COX-2 Inhibitors

N-acylated Sulfonamide Sodium Salt: A Prodrug of Choice for the Bifunctional 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) Benzenesulfonamide Class of COX-2 Inhibitors

Sunil Kumar Singh, Saibaba Vobbalareddy, Srinivasa Rao Kalleda, Seshagiri Rao Casturi, Ramesh Mullangi, Rajagopalan Ramanujam, Koteswar Rao Yeleswarapu, Javed Iqbal

Bioorg Med Chem Lett. 2006 Aug 1;16(15):3921-6.

PMID: 16730986

Abstract:

Synthesis and biological evaluation of possible prodrugs of COX-2 inhibitors involving sulfonamide and hydroxymethyl groups of 2-hydroxymethyl-4-(5-phenyl-3-trifluoromethyl-pyrazol-1-yl) benzenesulfonamides are described. Out of many options, the sodium salt of N-propionyl sulfonamide demonstrated much improved pharmacological profiles and physicochemical properties suitable for oral as well as parenteral administration.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42418036	N-(NBD-Aminododecanoyl)-1,2-ditetradecanoyl-sn-glycero-3-phosphoethanolamine sodium salt			Price

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