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The Influence of Urinary pH on Flecainide Excretion and Its Serum Pharmacokinetics

The Influence of Urinary pH on Flecainide Excretion and Its Serum Pharmacokinetics

K A Muhiddin, A Johnston, P Turner

Br J Clin Pharmacol. 1984 Apr;17(4):447-51.

PMID: 6326790

Abstract:

The effect of urinary pH on flecainide excretion has been evaluated in six healthy subjects after a single oral dose of 300 mg flecainide administered as the acetate salt. The cumulative urinary excretion of unchanged flecainide under acidic conditions (134.0 +/- 16.1 mg; mean +/- s.e. mean) was significantly higher than under alkaline conditions (22.3 +/- 7.6 mg; mean +/- s.e. mean) (P less than 0.01). Under alkaline conditions, tmax (time to reach peak concentration) was reduced (P less than 0.01), while elimination half-life, AUC(0-32) and AUC(0-infinity) were increased (P less than 0.01).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP54143565-B	Flecainide acetate salt		54143-56-5	Price

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