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The Rabbit Red Cell Antigen Hg A and anti-Hg A

The Rabbit Red Cell Antigen Hg A and anti-Hg A

M Frame, P L Mollison

Immunology. 1972 Jun;22(6):1037-42.

PMID: 5032487

Abstract:

The number of HgA sites on rabbit red cells was found to lie between 1.38 and 1.90 × 105 per cell in heterozygotes (HgAHgF) and between 3.0 and 3.8 × 105 per cell in homozygotes (HgAHgA).
The lowest concentration of IgG anti-HgA which could be detected using a `standard' indirect antiglobulin test was in the range 0.02-0.08 μg/ml.
The equilibrium constant of different examples of IgG anti-HgA lay between 0.5 and 1.56 × 1081/mole.
The ability of different examples of IgG anti-HgA to bind complement varied widely: some examples produced macroscopic haemolysis after 1-hour incubation with rabbit complement; one example produced no haemolysis even when the sensitive 51Cr-release method was used and failed to sensitize red cells to agglutination by anti-C3. The rate of haemolysis produced by haemolytic anti-HgA was very much less than that produced by haemolytic human anti-A.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414646	Anti-C3 antibody produced in rabbit			Price

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