The small molecule JIB-04 disrupts O 2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Barbara Cascella, Soon Goo Lee, Sukrit Singh, Joseph M Jez, Liviu M Mirica

Chem Commun (Camb). 2017 Feb 9;53(13):2174-2177.

PMID: 28144654

Abstract:

JIB-04, a specific inhibitor of the O2-activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2-consumption assay, X-ray crystal structure data, and molecular docking.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP199596059	JIB-04		199596-05-9	Price