JIB-04

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For Research Use Only | Not For Clinical Use
CATAP199596059
CAS199596-05-9
Molecular Weight308.76
Description≥98% (HPLC)
SolubilityDMSO: 10 mg/mL, clear
Assay≥98% (HPLC)
Colorwhite to beige
Formpowder
Size5MG, 25MG
Storage Conditions2-8°C

1Histone Lysine Dimethyl-Demethylase KDM3A Controls Pathological Cardiac Hypertrophy and Fibrosis

Qing-Jun Zhang, Tram Anh T Tran, Ming Wang, Mark J Ranek, Kristen M Kokkonen-Simon, Jason Gao, Xiang Luo, Wei Tan, Viktoriia Kyrychenko, Lan Liao, Jianming Xu, Joseph A Hill, Eric N Olson, David A Kass, etc.

Nat Commun. 2018 Dec 7;9(1):5230.

PMID: 30531796

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1JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway

Min Seong Kim, Hye In Cho, Hee Jung Yoon, Ye-Hyeon Ahn, Eun Jung Park, Yan Hua Jin, Yeun Kyu Jang

Sci Rep. 2018 Apr 26;8(1):6611.

PMID: 29700375

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1Targeting of Histone Demethylases KDM5A and KDM6B Inhibits the Proliferation of Temozolomide-Resistant Glioblastoma Cells

Massimo Romani, Antonio Daga, Alessandra Forlani, Maria Pia Pistillo, Barbara Banelli

Cancers (Basel). 2019 Jun 24;11(6):878.

PMID: 31238504

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1The Jumonji-domain Histone Demethylase Inhibitor JIB-04 Deregulates Oncogenic Programs and Increases DNA Damage in Ewing Sarcoma, Resulting in Impaired Cell Proliferation and Survival, and Reduced Tumor Growth

Janet K Parrish, Tyler S McCann, Marybeth Sechler, Lays M Sobral, Wenhua Ren, Kenneth L Jones, Aik Choon Tan, Paul Jedlicka

Oncotarget. 2018 Sep 4;9(69):33110-33123.

PMID: 30237855

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1The small molecule JIB-04 disrupts O 2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A

Barbara Cascella, Soon Goo Lee, Sukrit Singh, Joseph M Jez, Liviu M Mirica

Chem Commun (Camb). 2017 Feb 9;53(13):2174-2177.

PMID: 28144654

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