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Pyrrolizidine Alkaloids From Echium Rauwolfii and Echium Horridum (Boraginaceae)

Pyrrolizidine Alkaloids From Echium Rauwolfii and Echium Horridum (Boraginaceae)

A el-Shazly, M Abdel-All, A Tei, M Wink

Z Naturforsch C J Biosci. May-Jun 1999;54(5-6):295-300.

PMID: 10431383

Abstract:

Echimidine was isolated from Echium rauwolfii and Echium horridum and identified by MS, 1H- and 13C NMR as a major alkaloid. In addition, structures of 12 minor alkaloids were inferred from GLC and GLC-MS analyses: 7-angeloylretronecine, 7-tigloylretronecine, lycopsamine, 7-acetyllycopsamine, uplandicine, 7-angeloyllycopsamine, 7-tigloyllycopsamine, tigloyl isomer of echimidine, 7-angeloyl-9-(2-methylbutyryl)retronecine, 7-tigloyl-9-(2-methylbutyryl)retronecine, 7-angeloyl-9-(2,3-dihydroxybutyryl)retronecine, and 7-tigloyl-9-(2,3-dihydroxybutyryl)retronecine. Both species had similar alkaloid profiles. Alkaloid extracts exhibited antibacterial effects with a MIC of 1.7 mg/ml in E. coli. Microscopic examination of E. coli treated with different subtoxic alkaloid concentrations (13-52 micrograms/ml) revealed extensive filamentation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP73544486	7-Acetyllycopsamine		73544-48-6	Price

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