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1,2,3,4,6-penta-O-galloyl-beta-D-glucose From Galla Rhois Protects Primary Rat Hepatocytes From Necrosis and Apoptosis

1,2,3,4,6-penta-O-galloyl-beta-D-glucose From Galla Rhois Protects Primary Rat Hepatocytes From Necrosis and Apoptosis

Eun-Jeon Park, Yu-Zhe Zhao, Ren-Bo An, Youn-Chul Kim, Dong Hwan Sohn

Planta Med. 2008 Sep;74(11):1380-3.

PMID: 18622905

Abstract:

In this study, we investigated the hepatoprotective effects of four compounds from Galla Rhois [gallic acid methyl ester, gallic acid, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers, and 1,2,3,4,6-penta- O-galloyl- beta- D-glucose (PGG)] in primary rat hepatocytes undergoing necrosis or apoptosis. Treatment with gallic acid methyl ester (12.5 and 50 microM) or PGG (3.125, 12.5 and 50 microM) reduced hepatocyte necrosis induced by tert-butyl hydroperoxide. PGG treatment (4 and 20 microM) also altered hepatocyte apoptosis induced by glycochenodeoxycholic acid. Based on these results, we propose that PGG warrants further evaluation as a hepatoprotective agent, because it protected primary rat hepatocytes from both necrosis and apoptosis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP145434226	2,4,6-Triisopropylphenylboronic acid methyl ester		145434-22-6	Price

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