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1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic Acid (BAPTA-AM) Inhibits Caffeine-Induced Apoptosis in Human Neuroblastoma Cells

1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic Acid (BAPTA-AM) Inhibits Caffeine-Induced Apoptosis in Human Neuroblastoma Cells

Mi-Hyeon Jang, Min-Chul Shin, Young-Wuk Cho, Hyung-Hwan Baik, Sung-Soo Kim, Eun-Gu Hwang, Chang-Ju Kim

Neurosci Lett. 2004 Apr 1;358(3):189-92.

PMID: 15039113

Abstract:

In the present study, it was investigated whether 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid (BAPTA-AM), an intracellular Ca(2+) chelator, possesses protective effect against caffeine-induced apoptosis in the central nervous system. Through morphological and biochemical analyses, cells treated with caffeine exhibited several apoptotic features. On the other hand, cells treated with caffeine and BAPTA-AM, showed decreased occurrence of apoptotic features. In addition, it was shown that BAPTA-AM treatment inhibits caffeine-induced increase of caspase-3 enzyme activity. These results show that caffeine induces apoptotic death in human SK-N-MC neuroblastoma cells and BAPTA-AM prevents apoptosis by attenuating caffeine-induced caspase-3 activation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP85233198	1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid		85233-19-8	Price

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