Home
Resources
Publications
1,2-Dihydroxynaphthalene as Biomarker for a Naphthalene Exposure in Humans

1,2-Dihydroxynaphthalene as Biomarker for a Naphthalene Exposure in Humans

Katrin Klotz, Birgit Karin Schindler, Jürgen Angerer

Int J Hyg Environ Health. 2011 Mar;214(2):110-4.

PMID: 21147027

Abstract:

Objectives:
The possibly carcinogenic properties of naphthalene are, regarding to its ubiquitary presence, of environmental-medical and occupational-medical importance. Seven isomeric dihydroxynaphthalenes (DHN) were examined for their suitability as biomarkers in human biomonitoring and to get insights in human naphthalene metabolism.
Methods:
We developed a GC-MS-method for the quantification of 1,2-, 1,4-, 1,5-, 1,6-, 1,7-, 2,6- and 2,7-DHN after solid phase extraction and derivatization with BSA/TMCS. The internal burden of DHN after exposure to naphthalene was determined by measuring urine collected from smokers and non-smokers among the general population and among occupationally exposed persons.
Results:
The elaborated method can be regarded as specific and sensitive procedure to quantify the seven different DHN. In human urine, we detected 1,2-DHN as main metabolite in 54 of the 55 analysed samples. Median 1,2-DHN values (range) were 1012 μg/L (22-6477 μg/L) for workers and 8 μg/L (

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
DR5426	BSA+TMCS			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: