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1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) increases Carmofur stability and in vitro antiproliferative effect

Ilona Domracheva, Ruslan Muhamadejev, Marina Petrova, Edvards Liepinsh, Anita Gulbe, Irina Shestakova, Gunars Duburs, Pavel Arsenyan

Toxicol Rep. 2015 Jan 27;2:377-383.

PMID: 28962371

Abstract:

Addition of DMPC considerably inhibits the degradation of Carmofur in neutral phosphate buffer solutions and this drug becomes less influenced by pH. Carmofur stabilization at neutral pH caused by DMPC addition for in vitro studies was characterized and monitored by 1H NMR. Antiproliferative activity studies on various tumor cell lines showed considerable increase of Carmofur ability to prevent tumor cell growth, when it is added as a mixture with DMPC. This technique opens a way for Carmofur drug delivery in neutral and basic media.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18194246	1,2-Dimyristoyl-sn-glycero-3-phosphocholine		18194-24-6	Price

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