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1,3-Dibromo-5,5-dimethylhydantoin as Promoter for Glycosylations Using Thioglycosides

Fei-Fei Xu, Claney L Pereira, Peter H Seeberger

Beilstein J Org Chem. 2017 Sep 22;13:1994-1998.

PMID: 29062419

Abstract:

1,3-Dibromo-5,5-dimethylhydantoin (DBDMH), an inexpensive, non-toxic and stable reagent, is a competent activator of thioglycosides for glycosidic bond formation. Excellent yields were obtained when triflic acid (TfOH) or trimethylsilyl trifluoromethanesulfonate (TMSOTf) were employed as co-promoters in solution or automated glycan assembly on solid phase.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP60669694 Dibutylboryl trifluoromethanesulfonate solution Dibutylboryl trifluoromethanesulfonate solution 60669-69-4 Price
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