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1, 5-Dicaffeoylquinic Acid-Mediated Glutathione Synthesis Through Activation of Nrf2 Protects Against OGD/reperfusion-induced Oxidative Stress in Astrocytes

1, 5-Dicaffeoylquinic Acid-Mediated Glutathione Synthesis Through Activation of Nrf2 Protects Against OGD/reperfusion-induced Oxidative Stress in Astrocytes

Xu Cao, Haibing Xiao, Ying Zhang, Liangyu Zou, Yinghao Chu, Xiaofan Chu

Brain Res. 2010 Aug 6;1347:142-8.

PMID: 20513363

Abstract:

Oxidative stress plays an important role in pathological processes of cerebral ischemia followed by reperfusion. The effect of 1, 5-dicaffeoylquinic acid (1, 5-diCQA) on primary culture rat cortical astrocytes induced by oxygen and glucose deprivation (OGD)/reperfusion was evaluated in this study. Appropriate concentration of 1, 5-diCQA pretreatment significantly suppressed cell death, reduced the production of reactive oxygen species, prevented glutathione (GSH) depletion, increased the activity of glutamate-cysteine ligase (GCL), and triggered Nrf2 nuclear translocation in astrocytes induced by 4h of OGD and 20 h of reperfusion. Interestingly, these protective effects were greatly attenuated in Nrf2 siRNA-transfected cells. We conclude that 1, 5-diCQA has antioxidant signaling properties that upregulate GSH synthesis by stimulating the Nrf2 pathway in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19870463	1,5-Dicaffeoylquinic acid		19870-46-3	Price

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