0

1-Aminoindanes as Novel Motif With Potential Atypical Antipsychotic Properties

James M Graham, Linda L Coughenour, Bridget M Barr, David L Rock, Sham S Nikam

Bioorg Med Chem Lett. 2008 Jan 15;18(2):489-93.

PMID: 18160289

Abstract:

As part of an on-going effort to investigate the chemical space requirements for D(2)/5-HT(2A) receptor antagonists as atypical antipsychotics, new 1-aminoindanes were synthesized. The replacement of the heterocycle (oxindole) in ziprasidone with a carbocycle (indane) was well tolerated and was found to retain binding affinities for dopamine D(2), serotonin 5-HT(2A), and serotonin 5-HT(1A). Such compounds hold promise as a new chemical motif with atypical antipsychotic properties for the treatment of schizophrenia and related disorders.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1159977044 Ziprasidone Related Compound D Ziprasidone Related Compound D 1159977-04-4 Price
qrcode