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1-Ethyl-3-methylimidazolium Acetate as a Highly Efficient Organocatalyst for Cyanosilylation of Carbonyl Compounds With Trimethylsilyl Cyanide

Bakhtar Ullah, Jingwen Chen, Zhiguo Zhang, Huabin Xing, Qiwei Yang, Zongbi Bao, Qilong Ren

Sci Rep. 2017 Feb 15;7:42699.

PMID: 28198462

Abstract:

1-Ethyl-3-methylimidazolium acetate is introduced as a robust organocatalyst for solvent-free cyanosilylation of carbonyl compounds with trimethylsilyl cyanide (TMSCN). The catalyst loading can be reduced to as low as 0.1-0.0001 mol % under mild reaction conditions, giving considerably high TOF values from 10,843 h-1 to 10,602,410 h-1 in the field of organocatalyzed transformations. The present protocol not only tolerates with extensive carbonyl compounds but also provides somewhat insight into the mechanism of ionic liquids (ILs)-catalyzed reactions.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP143314174 1-Ethyl-3-methylimidazolium acetate 1-Ethyl-3-methylimidazolium acetate 143314-17-4 Price
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