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(1)H NMR Metabolomics to Study the Effects of Diazepam on Anisatin Induced Convulsive Seizures

(1)H NMR Metabolomics to Study the Effects of Diazepam on Anisatin Induced Convulsive Seizures

Pei Li, Dan-Dan Wei, Jun-Song Wang, Ming-Hua Yang, Ling-Yi Kong

J Pharm Biomed Anal. 2016 Jan 5;117:184-94.

PMID: 26361344

Abstract:

The anticonvulsive properties of diazepam have been extensively studied, mainly focusing on the γ-amino butyrate (GABA) system. The aim of this investigation was to integrally analyze the metabolic events related to neuroprotection of diazepam on anisatin-induced convulsive seizures by a NMR-based metabolomic approach combined with histopathological examination and behavior examination. Multivariate analysis on metabolic profiles of the piriform cortex and cerebellum of mice revealed that diazepam could relieve mice suffering from the convulsive seizures by recovering destructed neurotransmitter and neuromodulator metabolism, ameliorating oxidative stress, alleviating the disturbance in energy, amino acid and nucleic acid metabolism in anisatin intoxicated mice. This integrated metabolomics study provided a powerful and highly effective approach to elucidate therapeutic effects and assessed the safety of diazepam. This study should be helpful for our understanding of convulsive seizures, and provide a holistic view of the treatment effects of benzodiazepine on convulsive seizures.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP5230875	Anisatin		5230-87-5	Price

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