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1-O-n-octyl-beta-D-glucopyranoside as a Competitive Inhibitor of Na+-dependent D-glucose Cotransporter in the Small Intestine Brush-Border Membrane

1-O-n-octyl-beta-D-glucopyranoside as a Competitive Inhibitor of Na+-dependent D-glucose Cotransporter in the Small Intestine Brush-Border Membrane

M T Vincenzini, T Iantomasi, M Stio, C Treves, F Favilli, P Vanni

Biochim Biophys Acta. 1987 Oct 2;903(2):273-6.

PMID: 3651462

Abstract:

1-O-n-Octyl-beta-D-glucopyranoside is a competitive inhibitor of the Na+-dependent D-glucose uptake into rabbit, rat and human intestinal brush-border membrane vesicles. The lack of effect on the equilibrium uptake demonstrates that the detergent does not act by rupturing the vesicles; no membrane leakiness was apparent at the concentrations of octylglucopyranoside used, since D-glucose uptake is not inhibited even in the absence of the Na+ gradient (in K+ solution). There is a competitive interaction between octylglucopyranoside and D-glucose, as shown by Dixon and by Hunter and Down plots. The selectivity of the detergent effect is confirmed by its modest influence on amino acid uptake.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP29836268	Octyl β-D-glucopyranoside solution		29836-26-8	Price

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