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1'S-1'-Acetoxychavicol Acetate as a New Type Inhibitor of Interferon-Beta Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages

1'S-1'-Acetoxychavicol Acetate as a New Type Inhibitor of Interferon-Beta Production in Lipopolysaccharide-Activated Mouse Peritoneal Macrophages

Shin Ando, Hisashi Matsuda, Toshio Morikawa, Masayuki Yoshikawa

Bioorg Med Chem. 2005 May 2;13(9):3289-94.

PMID: 15809164

Abstract:

1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga was known to show potent inhibitory effect on the production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. To clarify its mechanism of action, the effects of 1'S-1'-acetoxychavicol acetate on the expression of interferon-beta (IFN-beta) mRNA and activation of nuclear factor-kappaB (NF-kappaB), both of which participate in the induction of inducible NO synthase, were examined in lipopolysaccharide-activated macrophages. The results were compared with those of two inhibitors of the NF-kappaB activation, costunolide and caffeic acid phenethyl ester. 1'S-1'-Acetoxychavicol acetate inhibited IFN-beta mRNA expression as well as NF-kappaB activation, and two related compounds, (+/-)-1-acetoxy-1-(2-acetoxyphenyl)-2-propene and (+/-)-1-acetoxy-1-(4-acetoxyphenol)-3-butene, also inhibited IFN-beta mRNA expression. In addition, 1'S-1'-acetoxychavicol acetate inhibited the production of NO stimulated by poly(I:C) via Toll-like receptor 3.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52946222	1′-Acetoxychavicol acetate		52946-22-2	Price

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