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10-Gingerol as an Inducer of Apoptosis Through HTR1A in Cumulus Cells:

10-Gingerol as an Inducer of Apoptosis Through HTR1A in Cumulus Cells:

Kiptiyah Kiptiyah, Widodo Widodo, Gatot Ciptadi, Aulanni'am Aulanni'am, Mohammad A Widodo, Sutiman B Sumitro

J Taibah Univ Med Sci. 2017 Jun 23;12(5):397-406.

PMID: 31435270

Abstract:

Objectives:
Cumulus cells play a crucial role as essential mediators in the maturation of ova. Ginger contains 10-gingerol, which induces apoptosis in colon cancer cells. Based on this hypothesis, this study aimed to determine whether 10-gingerol is able to induce apoptosis in normal cells, namely, cumulus cells.
Methods:
This study used an in vitro analysis by culturing Cumulus cells in M199 containing 10-gingerol in various concentrations (12, 16, and 20 μM) and later detected early apoptotic activity using an Annexin V-FITC detection kit.
Result:
The in vitro data revealed that the number of apoptosis cells increased along with the period of incubation as follows: 12 μM (63.71% ± 2.192%); 16 μM (74.51% ± 4.596%); and 20 μM (78.795% ± 1.435%). The substance 10-gingerol induces apoptosis in cumulus cells by inhibiting HTR1A functions and inactivating GSK3B and AKT-1.
Conclusions:
These findings indicate that further examination is warranted for 10-gingerol as a contraception agent.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23513157	[10]-Gingerol		23513-15-7	Price

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