Home
Resources
Publications
15N Conservation in the Metabolic Conversion of Isoleucine to Alloisoleucine in the Rat

15N Conservation in the Metabolic Conversion of Isoleucine to Alloisoleucine in the Rat

O A Mamer, F L Lépine

J Mass Spectrom. 1996 Dec;31(12):1382-8.

PMID: 8990521

Abstract:

15N,13C6-L-Isoleucine was given by stomach tube to a pair of rats and the urine excreted over the following 6 h period was collected. The urinary amino acid fraction showed that the majority of the L-alloisoleucine produced from the labeled isoleucine was formed with the 15N label intact. This fails to support the commonly held supposition that L-isoleucine and L-alloisoleucine interconversion occurs through the reversible enolization of the 2-keto-3-methylvaleric acids formed by their transamination. In contrast to 15N label conservation in L-alloisoleucine, the majority of the 15N in the administered L-isoleucine underwent exchange with 14N.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP202468357	L-Isoleucine-13C6,15N		202468-35-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: