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17-alpha Hydroxyprogesterone Caproate for Preterm Birth Prevention: Where Have We Been, How Did We Get Here, and Where Are We Going?

17-alpha Hydroxyprogesterone Caproate for Preterm Birth Prevention: Where Have We Been, How Did We Get Here, and Where Are We Going?

Tracy A Manuck

Semin Perinatol. 2017 Dec;41(8):461-467.

PMID: 28947068

Abstract:

Prematurity is a major public health problem in the United States and worldwide. Women with a history of a previous preterm birth are at high risk for recurrence. Progesterone is a key hormone involved in pregnancy maintenance. In general, progesterone is thought to maintain pregnancy through several closely linked mechanisms: (1) promotion of uterine quiescence, (2) inhibition of pro-inflammatory cells, and (3) immunosuppressive action. 17-Alpha hydroxyprogesterone caproate is currently the only medication approved to prevent recurrent preterm birth. The purpose of this review is to discuss the history of 17-alpha hydroxyprogesterone caproate use for recurrent preterm birth prevention, the rationale behind 17-alpha hydroxyprogesterone caproate administration, and current evidence-based indications for 17-alpha hydroxyprogesterone caproate use.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP630568	Hydroxyprogesterone caproate		630-56-8	Price

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