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18α-Glycyrrhetinic Acid Monoglucuronide as an Anti-Inflammatory Agent Through Suppression of the NF-κB and MAPK Signaling Pathway

Bo Li, Yongan Yang, Liuzeng Chen, Shichao Chen, Jing Zhang, Wenjian Tang

Medchemcomm. 2017 Jun 2;8(7):1498-1504.

PMID: 30108861

Abstract:

Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells. Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1449054 18α-Glycyrrhetinic acid 18α-Glycyrrhetinic acid 1449-05-4 Price
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