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2-(2-[[ O- 11 C]Tolyl)vinyl]-4,5-dihydro-1 H-imidazole

2-(2-[[ O- 11 C]Tolyl)vinyl]-4,5-dihydro-1 H-imidazole

Kam Leung

PMID: 22741184

Abstract:

Two major imidazoline binding sites (I1R and I2R) have been identified (1, 2). The I1R and I2R exhibit high affinities for clonidine and idazoxan, respectively. Clonidine and its analogs mediate effects independent of α2-adrenoceptorat the IR receptors. IR receptors are widely distributed in the central and peripheral nervous systems and in various organs such as the pancreas, liver, kidney, lung, and heart (3-6). I1R is associated with hypertension (7), whereas I2R is associated with depression (8), Alzheimer's disease (9), Parkinson's disease (10), Huntington's disease (10), and glial cell tumors (11). High densities of I2R have been observed in the arcuate nucleus, interpeduncular nucleus, pineal gland, and ventricles in human brain (12). The I2R gene has not been identified. Tesson et al. (13) showed that I2R is localized to the mitochondrial outer membrane of the human and rabbit liver. Pigini et al. (14) showed that 2-(2-[O-tolyl)vinyl]-4,5-dihydro-1H-imidazole (metrazoline) has a high and selective affinity for I2R. 2-(2-[[o-11C]Tolyl)vinyl]-4,5-dihydro-1H-imidazole ([11C]metrazoline) was evaluated as a PET probe for imaging of I2R in the peripheral tissues (15).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP221225043	Metrazoline		221225-04-3	Price

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