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2-Amino-4-(1-piperidine) Pyridine Exhibits Inhibitory Effect on Colon Cancer Through Suppression of FOXA2 Expression

2-Amino-4-(1-piperidine) Pyridine Exhibits Inhibitory Effect on Colon Cancer Through Suppression of FOXA2 Expression

Jieshu Wang, Bo Li, Kun Zhao, Xinyou Su

3 Biotech. 2019 Nov;9(11):384.

PMID: 31656722

Abstract:

The present study was aimed to investigate the effect of 2-amino-4-(1-piperidine) pyridine on migration and invasion of colon cancer cells. Treatment of colon cancer cells with 2-amino-4-(1-piperidine) pyridine reduced viability in concentration-based manner. The migration potential of HCT116 and HT29 cells was also suppressed on treatment with 2-amino-4-(1-piperidine) pyridine. In HCT116 and HT29 cells, apoptotic cell proportion was increased significantly by 2-amino-4-(1-piperidine) pyridine treatment. The expression of EMT and Vimentin in HCT116 and HT29 cells was reduced markedly on treatment with 2-amino-4-(1-piperidine) pyridine. The expression of E-cadherin was increased in HCT116 and HT29 cells by 2-amino-4-(1-piperidine) pyridine treatment. Treatment with 2-amino-4-(1-piperidine) pyridine reduced the expression of FOXA2 in HCT116 and HT29 cells. The 2-amino-4-(1-piperidine) pyridine treatment reduced growth of tumor in vivo in mice model. In summary, 2-amino-4-(1-piperidine) pyridine treatment inhibits colon cancer cell proliferation through down-regulation of FOXA2 expression. Therefore, 2-amino-4-(1-piperidine) pyridine can be used for the treatment of colon cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP913983218	5-Iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine		913983-21-8	Price
AP913983252	3-Iodo-1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridine		913983-25-2	Price

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